Sustained Renal Hypertension
نویسنده
چکیده
Antirenin to hog renin produced in the dog neutralizes the acute pressor effect of dog as well as hog renin. A course of intramuscular injections of hog renin in chronic renal hypertensive dogs produces an antihypertensive effect which is correlated with the antirenin titers of the plasma. Passive transfer of high titer homologous antiserum to hog renin produces an antihypertensive effect in chronic renal hypertensive dogs which is correlated with the antirenin titer. The results suggest a pathogenetic role for renin in experimental renal hypertension in the dog.
منابع مشابه
Persistent hypertension in the dog following disruption of the carotid sinus nerves and subsequent unilateral renal artery constriction.
CONSTRICTION of one renal artery in the dog does not as a rule produce sustained hypertension. Removal of the contralateral kidney, or bilateral renal artery constriction is necessary for the production of permanent hypertension. On the other hand, sustained hypertension may be produced regularly in the rat by unilateral renal artery constriction. Tt has been postulated that, in the rat, long s...
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